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Lipid vesicles deliver mRNA into cells

From The mRNA Journey: From Fragile Molecule to Programmable Medicine

  1. Research

    Lipid vesicles deliver mRNA into cells

    Liposomes carried globin mRNA into mouse cells, where it was translated into protein.

    Researchers wrapped mRNA that coded for a blood protein called globin inside tiny fat-based bubbles called liposomes, then delivered them into mouse cells. The cells read the instructions and built the protein. It was the first proof that mRNA didn't have to be injected naked into a cell, wrapping it in a protective fatty shell could get it there intact, an idea that became essential decades later when COVID-19 vaccines needed to survive the trip from syringe to cell.

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