Timeline milestone
Tumour-Infiltrating Lymphocytes Become an Approved Cell Therapy
From How Cancer Treatment Became Personal: From Chemotherapy to Precision Immunotherapy
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Regulatory
Tumour-Infiltrating Lymphocytes Become an Approved Cell Therapy
The first approved tumour-infiltrating lymphocyte therapy expanded immune cells collected from a patient's tumour and returned them in far greater numbers.
TIL therapy used immune cells that had already found the tumour, avoiding the need to design one synthetic receptor for every target. Approval in advanced melanoma broadened personalized cell therapy beyond CAR T, but intensive conditioning, specialized centres and manufacturing time remained substantial barriers.
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