Timeline milestone
Antifolate Treatment Produces Leukemia Remissions in Children
From How Cancer Treatment Became Personal: From Chemotherapy to Precision Immunotherapy
-
Clinical Milestone
Antifolate Treatment Produces Leukemia Remissions in Children
Sidney Farber used aminopterin to induce temporary remissions in childhood acute leukemia, showing that cancer metabolism could be attacked deliberately.
The remissions did not last, but the study converted chemotherapy from an accidental observation into a strategy based on cell biology. It also made clear that a single drug would rarely suppress an evolving cancer indefinitely.
Sources & references 1 source
