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Health 3 min read Oct 31

FDA Approves the First US Plasmid-DNA Immunotherapy

The FDA granted accelerated approval to Voceryq for adults with recurrent respiratory papillomatosis. The plasmid-DNA immunotherapy reduced surgery frequency in a small open-label trial, but confirmatory studies must still verify durable clinical benefit.

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How Plasmid-DNA Immunotherapy Delivers Genetic Instructions

Engineered plasmids carry genes into cells, which briefly produce selected antigens or immune signals that train the immune system without using a replicating pathogen.

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How a Malicious Code-Editor Extension Can Persist Outside Its Install Folder

Editor extensions can execute code with a developer's permissions, write SSH keys and startup files, and leave persistence behind even after the extension itself is removed.

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How Phage-Based Nanovaccines Display Tumor Antigens

Engineered bacteriophages can carry repeated tumor-antigen fragments on their protein shells while their DNA supplies an immune-stimulating signal, creating a genetically programmable vaccine scaffold.

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How Self-Hosting Changes the Security Boundary Around an AI Model

Self-hosting gives organizations control over data, access and customization, but it also transfers responsibility for isolation, authorization, monitoring and incident response from the model provider to the operator.

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Three common lithium-ion battery cell formats: cylindrical, prismatic and pouch.

Technology History 7 milestones Ongoing

The Battery That Electrified Everything: From Lithium Chemistry to Electric Cars

Diagram showing how an mRNA vaccine instructs cells to produce an antigen and trigger immunity.

Technology History 8 milestones Ongoing

The mRNA Journey: From Fragile Molecule to Programmable Medicine

Honda's ASIMO humanoid robot performs for students and U.S. President Barack Obama at Miraikan in Tokyo.

Technology History 9 milestones Ongoing

The Long Road to Humanoid Robots: From Walking Machines to AI Workers

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Mistral Released Large 4’s Weights With Cybersecurity as the Main Test

Artificial Intelligence

Oct 30•4 min

Mistral Released Large 4’s Weights With Cybersecurity as the Main Test

Mistral released downloadable weights for Large 4 after a three-week preview, giving security teams more control over deployment and customization. Its cyber and refusal scores are promising, but mostly benchmark-based, while permanent public access creates risks that provider safeguards cannot reverse.

Blood Tests and Liver-Stiffness Scans Could Spare Some Fatty-Liver Biopsies

Health

Oct 30•4 min

Blood Tests and Liver-Stiffness Scans Could Spare Some Fatty-Liver Biopsies

A prospective international study of more than 1,500 patients found several blood and liver-stiffness tests can detect advanced fibrosis and cirrhosis accurately enough to reduce some biopsies. Active MASH remains harder to diagnose non-invasively.