Timeline milestone
Personalized mRNA Vaccines Show Both Promise and Failure
From How Cancer Treatment Became Personal: From Chemotherapy to Precision Immunotherapy
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Setback
Personalized mRNA Vaccines Show Both Promise and Failure
Personalized vaccines advanced in melanoma while a colorectal-cancer trial was terminated after futility and a survival imbalance, showing that customization does not guarantee benefit.
NewTqnia Sequencing can identify mutations unique to a patient's tumour and encode selected targets in an mRNA vaccine. The strategy is highly personalized, but tumour biology still determines whether immune cells can recognize, enter and control the cancer. Conflicting results across tumour types made this setback a necessary milestone rather than a footnote.
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