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Checkpoint Inhibition Releases the Immune System's Brakes
From How Cancer Treatment Became Personal: From Chemotherapy to Precision Immunotherapy
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Regulatory
Checkpoint Inhibition Releases the Immune System's Brakes
Ipilimumab showed that blocking an immune checkpoint could extend survival in advanced melanoma, shifting treatment toward reactivating immunity rather than attacking the tumour directly.
UCLA Jonsson Comprehensive Cancer Center Checkpoint inhibitors can produce durable responses because immune cells adapt and persist, but only a subset of patients benefits. Removing immune restraints can also cause serious inflammation in healthy organs, making biomarkers and careful management central to treatment.
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